The PILR beta Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to Pilrb1. This antibody recognizes Human antigen. The PILR beta Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated has been validated for the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. PILRB is the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. There are three named isoforms produced by alternative splicing